Collapse of protein processes drives aging and death

A new Stony Brook University-led study published in Proceedings of the National Academy of Sciences (PNAS) provides a biophysical model that reveals how with age, damage accumulates in the shapes of cellular proteins and triggers death. Young cells remain healthy through the processes called chaperoning. As cells age, negative processes increase, reducing proteins’ ability to fold. One of these negative processes is oxidative damage, which the research team focuses on in its model. Once negative processes exceed positive ones, protein misfolding becomes rampant and cell death occurs. Read more here: